In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene that encodes the antigen binding site. This somatic hypermutation is restricted to immunoglobulin genes and occurs at very high rates. The precise molecular basis of this process remains obscure. However, recent studies using a variety of in vivo and in vitro systems have revealed important (...) regulatory regions, base motifs that are preferred targets of mutation and evidence that transcription may play an active role in hypermutation. BioEssays 20:227–234, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Working memory is the system responsible for maintaining and manipulating information, in the face of ongoing distraction. In turn, WM span is perceived to be an individual-differences construct reflecting the limited capacity of this system. Recently, however, there has been some evidence to suggest that WM capacity can increase through training, raising the possibility that training can functionally alter the neural structures supporting WM. To address the hypothesis that the neural substrates underlying WM are targeted by training, we conducted a (...) meta-analysis of functional magnetic resonance imaging studies of WM training using Activation Likelihood Estimation. Our results demonstrate that WM training is associated exclusively with decreases in blood oxygenation level-dependent responses in clusters within the fronto-parietal system that underlie WM, including the bilateral inferior parietal lobule, middle and superior frontal gyri, and medial frontal gyrus bordering on the cingulate gyrus. We discuss the various psychological and physiological mechanisms that could be responsible for the observed reductions in the BOLD signal in relation to WM training, and consider their implications for the construct of WM span as a limited resource. (shrink)

It will hardly come as a surprise to anybody even only remotely familiar with the general thrust and orientation of ‘Christian ethics’, that the question of euthanasia has been and still is seen in general as a moral disvalue and/or an evil that should be resisted. The bottom line of this approach is the theological notion that human life is a gift of the Creator and therefore a good to be nurtured, promoted and worth protection. Euthanasia, and especially its depenalization (...) and legalization to different degrees in the current laws of the Netherlands and Belgium, is evaluated as contrary to this requirement of protectability. Both during the debate on euthanasia and in reaction to various attempts to legislate on this matter, Christian churches in the Netherlands and Belgium have raised their voices and addressed the public at large, their own members and politicians in order to influence reflection and deliberation.In this article, I will first describe the argumentative way in which the major Christian churches in the Netherlands and Belgium have dealt with what they considered the challenge of the demand to legalize euthanasia in their respective countries. Given the important differences between the courses of events in both countries, the part on the interventions in the Netherlands will be considerably longer than the one on Belgium. No doubt, the most important reason for this difference is the fact that the public discussion on euthanasia together with efforts to change the penal law prohibiting it, took shape in the Netherlands already from 1968 on. Next to this, the fact that the major Christian churches in the Netherlands were not in agreement on the proper approach also contributes to a more differentiated picture. In the third part of this article, I will present some comments and a moral theological evaluation of the core of the argumentation forwarded by the Christian churches. (shrink)

The point of departure for this essay is a fourfold classification emerging from the European debate on the religious and ethical significance of the so-called Islamic headscarf, also known as hijab. Plurality promises a positive engagement in mapping multiculturalism toward intercultural dialogue and understanding. With a paradigm of an emergent intercultural ethics, the public leadership assumed by women in this debate testifies to the creativity by which imposed patterns of behavior are turned into strategies of resistance and liberation.

A simple but valuable experience that all humans have in common is that their life and their actions, the things they do and the things they omit to do, their reflection and their praxis are always marked by the tension which exists between what is factual and what is appropriate. Ethics can be described in simple terms as the systematic reflection on this tension, an endeavour to explicate how notions such as ‘appropriateness’ can be translated into categories such as ‘goodness’ (...) and ‘rightness’ in such a way that we do not remain bogged down in this experience but can develop some kind of assessment. One can also say, therefore, that ethics has a critical approach: the aforementioned tension is not merely noted and left at that, it is scrutinised, studied and assessed on the basis of a particular measure or criterion, thus making it possible, for example, to distinguish between the acknowledgement of changes and the appreciation of improvements .Every theory of ethics which consistently aspires to such a critical reflection, therefore, will have to deal with the question how the aforementioned criterion can be put into words. I already pointed to our common experience of the tension between the actual and the appropriate. In an effort to pin down the criterion in question, a useful point of departure might be to reflect for a moment on what is meant by appropriate. The term itself hints at some kind of relation or belonging to. If, then, the appropriate can be formulated in terms of belonging to ‘the human’ then an understanding of what it is to be human will always constitute the point of departure of any critical ethical reflection. For those who might be tempted to view this as too deductive, the whole approach can be turned on its head: the specific sort of reflection in which people engage with respect to the tension between the actual and the appropriate and in which the appropriate can be formulated in terms of the human, is ethics.[...]In the present article I intend to focus on the image of the human person which is compatible with such a notion of ethical obedience as responsibility to-be-taken-up. The fact that people speak today of a ‘changing of the guard’ when it comes to fundamental ethics is certainly no exaggeration. An ethics founded on natural law has been evolving towards the use of the notion personalism as a designation for an inclusive anthropology which is the expression of the appropriate. Experience teaches that a substantive explanation of personalism — which I provide in the third part of this article — is best preceded by a methodical sketch concerning the ‘status’ of personalism as a fundamental ethical category. In the fourth part of the article I will endeavour to outline the contours of a personalist theory of action. (shrink)

A simple but valuable experience that all humans have in common is that their life and their actions, the things they do and the things they omit to do, their reflection and their praxis are always marked by the tension which exists between what is factual and what is appropriate. Ethics can be described in simple terms as the systematic reflection on this tension, an endeavour to explicate how notions such as ‘appropriateness’ can be translated into categories such as ‘goodness’ (...) and ‘rightness’ in such a way that we do not remain bogged down in this experience but can develop some kind of assessment. One can also say, therefore, that ethics has a critical approach: the aforementioned tension is not merely noted and left at that, it is scrutinised, studied and assessed on the basis of a particular measure or criterion, thus making it possible, for example, to distinguish between the acknowledgement of changes and the appreciation of improvements .Every theory of ethics which consistently aspires to such a critical reflection, therefore, will have to deal with the question how the aforementioned criterion can be put into words. I already pointed to our common experience of the tension between the actual and the appropriate. In an effort to pin down the criterion in question, a useful point of departure might be to reflect for a moment on what is meant by appropriate. The term itself hints at some kind of relation or belonging to. If, then, the appropriate can be formulated in terms of belonging to ‘the human’ then an understanding of what it is to be human will always constitute the point of departure of any critical ethical reflection. For those who might be tempted to view this as too deductive, the whole approach can be turned on its head: the specific sort of reflection in which people engage with respect to the tension between the actual and the appropriate and in which the appropriate can be formulated in terms of the human, is ethics.[...]In the present article I intend to focus on the image of the human person which is compatible with such a notion of ethical obedience as responsibility to-be-taken-up. The fact that people speak today of a ‘changing of the guard’ when it comes to fundamental ethics is certainly no exaggeration. An ethics founded on natural law has been evolving towards the use of the notion personalism as a designation for an inclusive anthropology which is the expression of the appropriate. Experience teaches that a substantive explanation of personalism — which I provide in the third part of this article — is best preceded by a methodical sketch concerning the ‘status’ of personalism as a fundamental ethical category. In the fourth part of the article I will endeavour to outline the contours of a personalist theory of action. (shrink)

Recently, both in the Netherlands and in Belgium, legislation has been approved to depenalize »euthanasia «. From the background of a theological perspective and in the light of a justified aspiration for >death with dignity requirements of due care the gift of life<.

AGAINST THE BACKGROUND OF VARIOUS EUROPEAN LEGISLATIVE INITIAtlves dealing with medical-ethical decisions at the end of life and an introduction on the Belgian "Act on Euthanasia," in the first part of this essay I present a concise comparison between the Belgian law and the provisions of Dutch legislation. In the second part of the essay I aim at a better understanding of the Belgian legislation by documenting two opportunities that might have enhanced the outcome by addressing the complexity of end-of-life (...) decisions and the proper position of palliative care. I offer some preliminary conclusions in light of the implementation of the law in Catholic institutions as well as its first official evaluation. (shrink)

This paper has two parts: in the first an analytical reading is offered of the various definitions of ‘euthanasia’ as used by the magisterium of the Roman Catholic Church concluding that they lack precision; in the second a moral theological reading is offered of the claim that because life is a gift of God, humans are not having the right to dispose of life themselves. As a result, the paper tries to show that the language of ‘ownership’ is unfitting for (...) the ethical questions at hand. (shrink)

The Papal Encyclical Veritatis Splendor (1993) proposes a model of moral theology based on the notion of universal and unchanging ethical principles that guide the Christian moral life. It also helps to clarify a number of questions about the moral teachings of the Post-Vatican II Church. But Veritatis Splendor has not been received without some serious criticisms. Among the various reservations about the encyclical are that it misrepresents the current state of the questions in contemporary moral theology, that it parodies (...) the positions of a number of responsible moral theologians, and that it offers a vision of moral-theological issues that does not correspond to the world with which most professional and pastoral workers are familiar. The contributors to this volume - all leading professional Roman Catholic theologians - clearly interpret various key statements made by Veritatis Splendor and assess the overall accuracy of the encyclical's moral vision. In the process these essays also demonstrate the true significance of this important Church document for Christians today. (shrink)

In the paper ‘COVID-19 vaccine boosters for young adults: a risk–benefit assessment and ethical analysis of mandate policies at universities,’ Bardoshet alargued that college mandates of the COVID-19 booster vaccine are unethical. The authors came to this conclusion by performing three different sets of comparisons of benefits versus risks using referenced data and argued that the harm outweighs the risk in all three cases. In this response article, we argue that the authors frame their arguments by comparing values that are (...) not scientifically or reasonably comparable and that the authors used values that represent grossly different risk profiles and grouped them into a set of figures to create an illusion of fair comparisons. We argue that absent the falsely skewed portrayals of a higher level of risk over benefit in their misrepresented figures, the five ethical arguments they presented completely fall apart. (shrink)

It’s intuitive to think that an intentional action requires that the agent knows that she’s doing so. In light of some apparent counterexamples, Setiya suggests that this intuitive insight is better captured in terms of credence: performing an intentional action requires the agent to have a higher credence that she’s doing so than she would have otherwise. I argue that there is no such thing as an agent’s credence for what she’s doing. After distinguishing this thesis from an idea some (...) defend under the slogan “deliberation crowds out prediction”, I explore the thesis’s broader epistemological implications for the belief-credence relation. (shrink)

According to metaphysical coherentism, grounding relations form an interconnected system in which things ground each other and nothing is ungrounded. This potentially viable view’s logical territory remains largely unexplored. In this paper, I describe that territory by articulating four varieties of metaphysical coherentism. I do not argue for any variety in particular. Rather, I aim to show that not all issues which might be raised against coherentism will be equally problematic for all the versions of that view, which features far (...) more nuance and diversity than is typically ascribed to it. (shrink)

This paper considers whether Marx's views about communism change significantly during his lifetime. According to the ‘standard story’, as Marx got older he dropped the vision of self-realization in labour that he spoke of in his early writings, and adopted a more pessimistic account of labour, where real freedom is achieved outside the working-day, in leisure. Other commentators, however, have argued that there is no pessimistic shift in Marx's thought on this matter. This paper offers a different reading of this (...) debate. It argues that there are two visions of the good life in Marx. However, it suggests that these two visions cannot be understood in terms of a simple shift between a ‘young’ and ‘mature’ Marx. Rather, it claims that Marx moves between these two visions throughout his writings. In this way, it suggests that Marx's intellectual development on this issue is best understood as an oscillation rather than a shift. Once this interpretive claim is advanced, the paper then moves on to consider some potential causes and implications of Marx's life-long oscillation between two different conceptions of the good life. (shrink)

Representing the thinking of philosophers, psychologists, sociologists, coaches, and sports writers, these essays bring together a wide range of approaches to ...

Der Band enthält Beiträge von Medizinern, Juristen, Philosophen und Naturwissenschaftlern aus Estland, Polen, den Niederlanden und Deutschland zu Themen der Ethik und Wissenschaftstheorie der Medizin. Diese Beiträge sind im Rahmen des «Arbeitskreises für Ethik und Wissenschaftstheorie der Medizin in Ostmitteleuropa» entstanden, der auf einer Kooperationsvereinbarung des Interdisziplinären Zentrums für Ethik der Europa-Universität Viadrina Frankfurt (Oder) und des Instituts für Geschichte und Ethik der Medizin der Universität Halle-Wittenberg beruht. Sie befassen sich u. a. mit der Gesundheitsreform in Polen, Tschechien und Ungarn, (...) mit ethischen Problemen bei Abtreibung, HIV-Infektion, Drogenkonsum, Sterbehilfe und Gentechnik sowie dem Theorie-Praxis-Verhältnis in der Medizin. (shrink)

1. cilt. İnsan, evren, zaman -- 2. cilt. Yaradılış.

This study clarifies the need for a renewed account of the body in physiotherapy to fill sizable gaps between physiotherapeutical theory and practice. Physiotherapists are trained to approach bodily functioning from an objectivist perspective; however, their therapeutic interactions with patients are not limited to the provision of natural-scientific explanations. Physiotherapists’ practice corresponds well to theorisation of the body as the bearer of original bodily intentionality, as outlined by Merleau-Ponty and elaborated upon by enactivists. We clarify how physiotherapeutical practice corroborates Merleau-Ponty’s (...) critical arguments against objectivist interpretations of the body; particularly, his analyses demonstrate that norms of optimal corporeal functioning are highly individual and variable in time and thus do not directly depend on generic physiological structures. In practice, objectively measurable physical deviations rarely correspond to specific subjective difficulties and, similarly, patients’ reflective insights into their own motor deficiencies do not necessarily produce meaningful motor improvements. Physiotherapeutical procedures can be understood neither as mechanical manipulations of patients’ machine-like bodies by experts nor as a process of such manipulation by way of instructing patients’ explicit conscious awareness. Rather, physiotherapeutical practice and theory can benefit from the philosophical interpretation of motor disorders as modifications of bodily intentionality. Consequently, motor performances addressed in physiotherapy are interpreted as relational features of a living organism coupled with its environment, and motor disorders are approached as failures to optimally manage the motor requirements of a given situation owing to a relative loss of the capacity to structure one’s relation with their environment through motor action. Building on this, we argue that the process of physiotherapy is most effective when understood as a bodily interaction to guide patients towards discovering better ways of grasping a situation as meaningful through bodily postures and movements. (shrink)

An agent’s knowledge of her own intentional actions (agential knowledge) is non-observational. Yet, intentional actions typically consist of happenings external to the agents. A theory is needed to explain how agents are warranted to form such beliefs independent of observation. This paper first argues for three desirable features of an ideal theory about agential knowledge. After showing that no existing theories possess all three, a novel theory that does is presented. According to this theory, agential knowledge is the same kind (...) of knowledge as the Kripkean contingent a priori: they are knowledge justified a priori by stipulation. (shrink)

The paper argues that there are structures rather than objects with an intrinsic identity in the domain of fundamental physics. We line out the standard metaphysics of objects with an intrinsic identity, recall the main objection against that position (section 1) and then retrace the development to epistemic structural realism (section 2) and to ontic structural realism (section 3). We elaborate on the arguments for ontic structural realism from quantum physics (section 4) and from space-time physics (section 5). Finally, we (...) claim that the main objection against the standard metaphysics of objects with an intrinsic identity is countered by structural realism only if the fundamental physical structures are conceived as causal structures (section 6). (shrink)

Luitzen Egburtus Jan Brouwer founded a school of thought whose aim was to include mathematics within the framework of intuitionistic philosophy; mathematics was to be regarded as an essentially free development of the human mind. What emerged diverged considerably at some points from tradition, but intuitionism has survived well the struggle between contending schools in the foundations of mathematics and exact philosophy. Originally published in 1981, this monograph contains a series of lectures dealing with most of the fundamental topics such (...) as choice sequences, the continuum, the fan theorem, order and well-order. Brouwer's own powerful style is evident throughout the work. (shrink)

This paper clarifies Merleau-Ponty’s original account of “higher-order” cognition as fundamentally embodied and enacted. Merleau-Ponty’s philosophy inspired theories that deemphasize overlaps between conceptual knowledge and motor intentionality or, on the contrary, focus exclusively on abstract thought. In contrast, this paper explores the link between Merleau-Ponty’s account of motor intentionality and his interpretations of our capacity to understand and interact productively with cultural symbolic systems. I develop my interpretation based on Merleau-Ponty’s analysis of two neuropathological modifications of motor intentionality, the case (...) of the brain-injured war veteran Schneider, and a neurological disorder known as Gerstmann’s syndrome. Building on my analysis of Schneider’s sensorimotor compensatory performances in relation to his limitations in the domains of algebra, geometry, and language usage, I demonstrate a strong continuity between the sense of embodiment and enaction at all these levels. Based on Merleau-Ponty’s interpretations, I argue that “higher-order” cognition is impaired in Schneider insofar as his injury limits his sensorimotor capacity to dynamically produce comparatively more complex differentiations of any given phenomenal structure. I then show how Merleau-Ponty develops and specifies his interpretation of Schneider’s intellectual difficulties in relation to the ambiguous role of the body, and in particular the hand, in Gerstmann’s syndrome. I explain how Merleau-Ponty defends the idea that sensorimotor and quasi-representational cognition are mutually irreducible, while maintaining that symbol-based cognition is a fundamentally enactive and embodied process. (shrink)

Marx’s vision of unalienated production is often thought to be subject to decisive objections. This article argues that these objections rely on a misinterpretation of Marx’s position. It provides a new interpretation of Marx’s vision of unalienated production. Unlike another well-known account, it suggests that unalienated production involves realizing oneself through providing others with the goods and services they need for their self-realization. It argues that this view is appealing and that it offers a more successful response to objections than (...) previous interpretations. In doing so, it hopes to put Marx’s concern with alienation and nonalienation back on the table. (shrink)

This paper provides an analysis of the intrinsic/extrinsic distinction, as applied both to properties and to relations. In contrast to other accounts, the approach taken here locates the source of a property’s intrinsicality or extrinsicality in the manner in which that property is ‘logically constituted’, and thus – plausibly – in its nature or essence, rather than in e.g. its modal profile. Another respect in which the present proposal differs from many extant analyses lies in the fact that it does (...) not seek to analyse the ‘global’ distinction between intrinsic and extrinsic properties on the basis of the ‘local’ distinction between having a property intrinsically and having it extrinsically. Instead, the latter distinction is explicated on the basis of the former. (shrink)

On conduct of life and ethics of Islamic seminarians.

Terugblik van de bekende psychiater op zijn ontwikkeling als sannyasin.

Dealing with conflicts seems to be a great challenge in society today. But not only in society. Higher education displays an air of resoluteness with certainty and security that disguises the conflicts and the fear of conflicts in a substantial number of subjects. If not in a state of denial, higher education avoids taking up conflicts over issues, for learning. The detailed investigation of Tagore’s pedagogical writings, with a focus on the importance of conflicts in education, reveals a genuine embrace (...) of conflicts for education. Conflicts are natural and necessary for the development and change of both the individual and society and the start of a ‘creative imagination’ to solve the problems we face in life. Contradictions in conflicts are not incompatible incongruities that are irreconcilable and mutually exclusive, but to the contrary, in need of each other. Contradictions do not represent different worlds but are substantial parts of one world: together they form a unity. Conflicting forces are necessary to create harmony. Creativity, imagination, love, art, and critical encounters are key elements in Tagore’s practical education aimed at finding similarities among people instead of emphasizing differences. Relations between people over the Identity of people. In other words, we need conflicts to become creative and imaginative human beings. The paper continues discussing conceptual and practical issues that seem necessary to get the teaching of conflicts in education off the ground. On the conceptual level, in particular our dealing with uncertainty and fear, the valuation of conflict and the need for uncertainty-researching education. On a practical level, I propose a certain teaching model, a supportive curriculum, a way of choosing genuine conflicts for education and finally, I argue for specific support and education of teachers, acknowledging the vital role teachers play in delivering the education that we need. (shrink)

This paper sets out a moderate version of metaphysical structural realism that stands in contrast to both the epistemic structural realism of Worrall and the—radical—ontic structural realism of French and Ladyman. According to moderate structural realism, objects and relations (structure) are on the same ontological footing, with the objects being characterized only by the relations in which they stand. We show how this position fares well as regards philosophical arguments, avoiding the objections against the other two versions of structural realism. (...) In particular, we set out how this position can be applied to space-time, providing for a convincing understanding of space-time points in the standard tensor formulation of general relativity as well as in the fibre bundle formulation. (shrink)

International institutions such as UNESCO are deliberating on a new standard setting instrument for neurotechnologies. This will likely lead to the adoption of a soft law document which will be the first global document specifically tailored to neurotechnologies, setting the tone for further international or domestic regulations. While some stakeholders have been consulted, these developments have so far evaded the broader attention of the neuroscience, neurotech, and neuroethics communities. To initiate a broader debate, this target article puts to discussion twenty-five (...) considerations and desiderata for recognition by a future instrument. They are formulated at different levels of abstraction, from the big picture to technical details, seek to widen the perspective of preparatory reports and transcend the narrow debate about “neurorights” which overshadows many richer and more relevant aspects. These desiderata are not an exhaustive enumeration but a starting point for discussions about what deserves and what requires protection by an international instrument. (shrink)

This paper is my commentary on Raymond Tallis’ book Freedom: An Impossible Reality (2021). Tallis argues that the laws described by science are dependent on human agency which extracts them from nature. Consequently, human agency cannot be explained as an effect of natural laws. I agree with Tallis’ main argument and I appreciate that he helps us understand the systematic importance of a human-scale breadth of view regarding any theoretical investigation. In the main part of the paper, I critically comment (...) on Tallis’ interpretation of several more loosely associated topics from a phenomenological perspective. Firstly, I reconsider Tallis’ account of intentionality as a factor that opens a distance between the cognizer and the world. Whereas Tallis emphasizes that agency requisitions aspects of the world to achieve its goals, I point out that agency does not determine the meaning of things unidirectionally and independently of all context. A self-controlled agency is provisionally reached through a process of ‘deindexicalization’ of our passive intentional capacities, that is, by creating and maintaining new, different worldly contexts. Subsequently, I analyze Tallis’ description of our intentional relation to spatiotemporally distant possibilities. In my view, Tallis underestimates the extent to which our intentional relation to possibilities is pre-reflexive and pre-predicative and hence independent of propositional attitudes. Finally, I consider Tallis’ interpretation of nature and show that it is deeply influenced by the sciences of nature. In contrast, I argue that agency can be properly described only if we understand it as an intervention in a lifeworld already imbued with sense, not merely a physical or material nature. (shrink)

There is concern that the use of neuroenhancements to alter character traits undermines consumer's authenticity. But the meaning, scope and value of authenticity remain vague. However, the majority of contemporary autonomy accounts ground individual autonomy on a notion of authenticity. So if neuroenhancements diminish an agent's authenticity, they may undermine his autonomy. This paper clarifies the relation between autonomy, authenticity and possible threats by neuroenhancements. We present six neuroenhancement scenarios and analyse how autonomy accounts evaluate them. Some cases are considered (...) differently by criminal courts; we demonstrate where academic autonomy theories and legal reasoning diverge and ascertain whether courts should reconsider their concept of autonomy. We argue that authenticity is not an appropriate condition for autonomy and that new enhancement technologies pose no unique threats to personal autonomy. (shrink)

Insight problem solving is thought to underpin creative thought as it incorporates both divergent (generating multiple ideas and solutions) and convergent (arriving at the optimal solution) thinking approaches. The current literature on schizotypy and creativity is mixed and requires clarification. An alternate approach was employed by designing an exploratory web-based study using only correlates of schizotypal traits (paranoia, dissociation, cognitive failures, fantasy proneness, and unusual sleep experiences) and examining which (if any) predicted optimal performance on an insight problem-solving task. One (...) hundred and twenty-one participants were recruited online from the general population and completed the number reduction task. The discovery of the hidden rule (HR) was used as a measure of insight. Multivariate logistic regression analyses highlighted persecutory ideation to best predict the discovery of the HR (OR = 1.05; 95% CI 1.01–1.10, p = 0.017), with a one-point increase in persecutory ideas corresponding to the participant being 5% more likely to discover the HR. This result suggests that persecutory ideation, above other schizotypy correlates, may be involved in insight problem solving. (shrink)